Thrombotic Thrombocytopenic Purpura Induced by Acute Pancreatitis

Socrates G Roedan, MD, Nihar N Shah, MD, Robert Spira, MD

Abstract


Thrombotic thrombocytopenic purpura (TTP) is a rare blood disorder characterized by clotting in small blood vessels of the body (microthrombi), resulting in a low platelet count. The disease consists of the pentad of microangiopathic hemolytic anemia, thrombocytopenic purpura, neurologic abnormalities, fever and renal disease. Many symptoms could develop with acute pancreatitis but being able to differentiate when it is associated with any hematological conditions such as TTP is crucial to initiate a proper medical treatment. We present a rare case of a thirty-eight years old African American female, who presented to the Emergency department with an abdominal pain associated with a pancreatic condition. A vital piece in medical practice is recognizing lifesaving decisions in critical conditions cases.  Acute Pancreatitis (AP) is a well-described consequence of TTP but acute pancreatitis triggering TTP is still not as frequent. 

[N A J Med Sci. 2016;9(2):75-77.   DOI:  10.7156/najms.2016.0902075]


Keywords


acute pancreatitis, TTP, HUS, ADAMTS13, MAHA

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References


Reese JA, Muthurajah DS, Kremer Hovinga JA, et al. Children and adults with thrombotic thrombocytopenic purpura associated with severe, acquired Adamts13 deficiency: comparison of incidence, demographic and clinical features. Pediatr Blood Cancer. 2013; 60:1676-1682.

Scully M, Yarranton H, Liesner R, et al. Regional UK TTP Registry: Correlation with laboratory ADAMTS 13 analysis and clinical features. Br J Haematol. 2008;142:819-826.

Vesely SK, George JN, Lammle B, et al. ADAMTS13 activity in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: Relation to presenting features and clinical outcomes in a prospective cohort of 142 patients. Blood. 2003;102:60-68.

Varadarajulu S, Ramsey WH, Israel RH, et al. Thrombotic thrombocytopenic purpura in acute pancreatitis. J Clin Gastroenterol. 2000;31:243-245.

Gullo L, Cavichhi L, Tomassetti P, et al. Effects of ischemia on the human pancreas. Gastroenterology. 1996;111:1033-1038.

Ruggenenti P, Remuzzi G. Thrombotic thrombocytopenic purpura and related disorders. Hematol Oncol Clin North Am. 1990;4:219-241.

Leaf AN, Laubenstein LJ, Raphael B, et al. Thrombotic thrombocytopenic purpura associated with human immunodeficiency virus type Iinfection. Ann Intern Med. 1988;109:194-197.

Gullo L, Cavichhi L, Tomassetti P, et al. Effects of ischemia on the human pancreas. Gastroenterology. 1996;111:1033-1038.

Shepard KV, Bukowski RM. The treatment of thrombotic thrombocytopenic purpura with exchange transfusion, plasma infusion, and plasma exchange. Semin Hematol. 1987;24:178-186.

Gillis S. The thrombocytopenic purpuras: Recognition and management. Drugs. 1996;51:942-953.


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