Rare Breast Granular Cell Tumor with Alpha-1 Antitrypsin Expression: A Case Report and Literature Review

Zhengtong Pei, MD, Shiyu Wang, BS, He Wang, MD, PhD

Abstract


Breast granular cell tumors are rare benign tumors with clinical and radiological resemblance to mammary carcinoma. Definitive diagnosis usually needs tissue or fine needle aspiration based cellular examination. Special stains, including PAS, PASD, S-100 and CK, are very important for reaching the correct diagnosis. However, the current markers to differentiate this tumor from histiocytes, including α-1-antitrypsin, α-1-antichymotrypsin and CD68, are not very specific.  Both α-1-antitrypsin and CD68 are positive in our case.  A more extensive panel of histiocytic markers should be tested to evaluate their differential utility between histiocytes and GCTs, especially breast GCTs.

[N A J Med Sci. 2013;6(2):103-106.   DOI:  10.7156/najms.2013.0602103]



Keywords


breast granular cell tumors (GCTs); alpha-1 antitrypsin, immunohistochemistry, literature review

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References


Abrikossoff A. Über Myome, ausgehend von der quergestreiften willkürlichen Muskulatur. Virchows Arch Pathol Anat Physiol. 1926;260:215–233.

Mukai M. Immunohistochemical localization of S-100 protein and peripheral nerve myelin proteins (P2 protein, P0 protein) in granular cell tumors. Am J Pathol. 1983;112(2):139–146.

Rosso R, Scelsi M, Carnevali L: Granular cell traumatic neuroma: a lesion occurring in mastectomy scars. Arch Pathol Lab Med. 2000;124(5):709-711.

Gavriilidis P, Michalopoulou I, Baliaka A, Nikolaidou A. Granular cell breast tumour mimicking infiltrating carcinoma. BMJ Case Rep. 2013;2013.

Lack EE, Worsham GF, Callihan MD, Crawford BE, Klappenbach S, Rowden G, Chun B. Granular cell tumor: a clinicopathological study of 110 patients. J Surg Oncol. 1980;13(4):301–316.

Buley ID, Gatter KC, Kelly PM, Heryet A, Millard PR. Granular cell tumours revisited. An immunohistological and ultrastructural study. Histopathology 1988;12(3):263-274.

Willén R, Willén H, Balldin G, Albrechtsson U. Granular cell tumour of the mammary gland simulating malignancy. A report on two cases with light microscopy, transmission electron microscopy and immunohistochemical investigation. Virchows Arch A Pathol Anat Histopathol. 1984;403(4):391-400.

Raju GC, O'Reilly AP. Immunohistochemical study of granular cell tumour. Pathology. 1987;19(4):402-406.

Filie AC, Lage JM, Azumi N. Immunoreactivity of S100 protein, alpha-1-antitrypsin, and CD68 in adult and congenital granular cell tumors. Mod Pathol. 1996;9(9):888-892.

Le BH, Boyer PJ, Lewis JE, Kapadia SB. Granular cell tumor immunohistochemical assessment of inhibin-alpha, protein gene product 9.5, S100 protein, CD68, and Ki-67 proliferative index with clinical correlation. Arch Pathol Lab Med. 2004;128(7):771–775.

Khansur T, Balducci L, Tavassoli M. Granular cell tumor. Clinical spectrum of the benign and malignant entity. Cancer. 1987;60(2):220–222.

Fanburg Smith JC, Meis Kindblom JM, Fante R, Kindblom LG. Malignant granular cell tumor of soft tissue: Diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol. 1998;22(7):779–794.

Mahoney A, Garg A, Wolpowitz D, Mahalingam M. Atypical granular cell tumor - apropos of a case with indeterminate malignant potential. Am J Dermatopathol. 2010;32(4):370–373.

Unal E, Firat A, Gunes P, Kilicoglu G, Gulkilik A, Titiz I. Apocrine carcinoma of the breast: clinical, radiologic, and pathologic correlation. Breast J. 2007;13(6):617–618.

Aneiros-Fernandez J, Arias-Santiago S, Husein-Elahmed H, Ovalle F, Siendones MI, Aneiros-Cachaza J. Cutaneous granular cell tumor of the breast: a clinical diagnostic pitfall. J Clin Med Res. 2010;2(4):185-188.


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