Neuroinflammation and Autism

Qing M. Wang, Andrew Z. Luo, Xuejun Kong

Abstract


The incidence of autism spectrum disorder (ASD) has increased significantly in the past decades, now affecting 1 out of 68 children in USA. The complexity of this disorder and the unclear mechanisms have hindered the development of an effective therapeutic regimen. Recent studies have suggested that neuro-inflammation plays an important role in the pathogenesis of ASD. A literature review was conducted to examine the evidence of various central immune processes involved in ASD. Conventional and novel medications for ASD treatment were summarized.


Keywords


autism, neuro-inflammation, mast cell, microglia, astrocyte, medication

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References


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