Involvement of Voltage-Gated Ca2+ Channels in Autism Spectrum Disorders

Angela L. Wang, Feng Liu, Gang Wang


Substantial evidence suggests that mutated voltage-gated L-type Ca2+ channel subunit CaV1.2 (CACNAIC) is involved in pathophysiology of autism spectrum disorder (ASD), as exemplified by recent findings that mutated CACNAIC and other L-type Ca2+ channels play an important role in pathophysiology of Timothy Syndrome and Fragile X Syndrome, genetic syndromes of ASD. This review will focus on recent advances in our understanding of the genetic mutation of the CaV1.2 L-type channels in ASD, and highlight the potential roles of CaV1.2 channels in the pathogenesis of ASD. 


autism spectrum disorders, Ca2+ channels, Timothy syndrome, Fragile X sydrome

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