The Pathology of Pemphigus: A Mini-Review
Keywords:
Pemphigus, histopathology, skin biopsiesAbstract
Pemphigus is a rare group of blistering autoimmune diseases that affect the skin and mucous membranes. Variants of pemphigus are now known to be associated with certain medications, underlying malignancy and even an endemic form is well recognized. Following the discovery of the autoimmune basis of pemphigus, specific treatment regimens have made strides in significantly reducing the morbidity and mortality once associated with the disease. Traditional histopathology and tissue based techniques have played a pivotal role in the understanding of pemphigus and in highlighting the diversity within this group of diseases. The examination of skin biopsies by light microscopy and immunofluorescence remains the standard for diagnosis today.
References
Masayuki A. Pemphigus. In: Bolognia, JL, Jorizzo, JL, Rapini, RP, eds. Dermatology 2nd Edition. New York: Mosby: 2008:417-429.
Warren SJ, Lin MS, Giudice GJ, et al. The prevalence of antibodies against desmoglein 1 in endemic pemphigus foliaceus in Brazil. N Engl J Med. 2000;343(1):23-30.
Guillen S, Khachemoune A. Pemphigus vulgaris: a short review for the practitioner. Dermatol Nurs. 2007;19(3):269-272.
Anhalt GJ, Dıaz LA. Pemphigus vulgaris – a model for cutaneous autoimmunity. J of Am Acad of Dermatol. 2004;51(1 Suppl):S20-1.
Weedon D. The vesicobullous reaction pattern. In: Weedon D. Skin Pathology 3rd Edition. New York: Elsevier; 2010:123-168
Beutner EH, Jordon RE. Demonstration of skin antibodies in sera of pemphigus vulgaris patients by indirect immunofluorescent staining. Exp Biol Med. 1964;117(2):505-510.
Jordon RE, Triftshauser CT, Schroeter AL. Direct immunofluorescent studies of pemphigus and bullous pemphigoid. Arch. Derm. 1971;103(5):486-491.
Maize JC, Freen D, Provost TT. Pemphigus foliaceus: a case with serologic features of Senear-Usher syndrome and other autoimmune abnormalities. J Am Acad Dermatol. 1982;7(6):736-741.
Reich A, Marcinow K, Bialynicki-Birula R. The lupus band test in systemic lupus erythematosus patients. Ther Clin Risk Manag. 2011;7:27-32.
Robinson ND, Hashimoto T, Amagai M, et al. The new pemphigus variants. J Am Acad Dermatol. 1999;40(5):649-671.
Garrod D, Chidgey M. Desmosome structure, composition and function. Biochem Biophys Acta. 2008;1778(3):572-587.
Denning MF, Guy SG, Ellerbroek SM, et al. The expression of demoglein isoforms in cultured human keratinocytes is regulated by calcium, serum and protein kinase C. Exp Cell Res. 1998;239(1):50-59.
Stanley JR, Koulo L, Thivolet C. Distinction between epidermal antigens binding pemphigus vulgaris and pemphigus foliaceus autoantibodies. J Clin Invest. 1984;74(2):313-320.
Amagai M, Klaus-Kovtun V, Stanley JR. Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. Cell. 1991;67(5):869-877.
Merlob P, Metzker A, Hazaz B et al. Neonatal pemphigus vulgaris. Pediatrics. 1986;78(6):1102-1105.
Anhalt GJ, Labib RS, Voorhees JJ, et al. Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease. N Engl J Med. 1982;306(20):1189-1196.
Amagai M, Tsunoda K, Zillikens D, et al. The clinical phenotype of pemphigus is defined by the anti-desmoglein autoantibody profile. J Am Acad Dermatol. 1999;40(2):167-170.
Mahoney MG, Wang Z, Rothenberger K, et al. Explanation for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris. J Clin Invest. 1999;103(4):461-468.
Anhalt GJ, Kim SC, Stanley JR, et al. Paraneoplastic pemphigus. An autoimmune mucocutaneous disease associated with neoplasia. N Engl J Med. 1990;323(25):1729-1735.
Ho VC, Stein HB, Ongley RA, et al. Penicillamine induced pemphigus. J of Rheumatol. 1985;12(3):583-586.
Diaz LA, Sampaio S, Rivitti EA, et al. Endemic pemphigus foliaceus (fogo selvagem): Current and historical epidemiological aspects. J Invest Dermatol. 1989;92(1):4-12.
Warren SJ, Lin MS, Giudice GJ, et al. The prevalence of antibodies against desmoglein 1 in endemic pemphigus foliaceus in Brazil. N Engl J Med. 2000;343(1):23-30.
Guillen S, Khachemoune A. Pemphigus vulgaris: a short review for the practitioner. Dermatol Nurs. 2007;19(3):269-272.
Anhalt GJ, Dıaz LA. Pemphigus vulgaris – a model for cutaneous autoimmunity. J of Am Acad of Dermatol. 2004;51(1 Suppl):S20-1.
Weedon D. The vesicobullous reaction pattern. In: Weedon D. Skin Pathology 3rd Edition. New York: Elsevier; 2010:123-168
Beutner EH, Jordon RE. Demonstration of skin antibodies in sera of pemphigus vulgaris patients by indirect immunofluorescent staining. Exp Biol Med. 1964;117(2):505-510.
Jordon RE, Triftshauser CT, Schroeter AL. Direct immunofluorescent studies of pemphigus and bullous pemphigoid. Arch. Derm. 1971;103(5):486-491.
Maize JC, Freen D, Provost TT. Pemphigus foliaceus: a case with serologic features of Senear-Usher syndrome and other autoimmune abnormalities. J Am Acad Dermatol. 1982;7(6):736-741.
Reich A, Marcinow K, Bialynicki-Birula R. The lupus band test in systemic lupus erythematosus patients. Ther Clin Risk Manag. 2011;7:27-32.
Robinson ND, Hashimoto T, Amagai M, et al. The new pemphigus variants. J Am Acad Dermatol. 1999;40(5):649-671.
Garrod D, Chidgey M. Desmosome structure, composition and function. Biochem Biophys Acta. 2008;1778(3):572-587.
Denning MF, Guy SG, Ellerbroek SM, et al. The expression of demoglein isoforms in cultured human keratinocytes is regulated by calcium, serum and protein kinase C. Exp Cell Res. 1998;239(1):50-59.
Stanley JR, Koulo L, Thivolet C. Distinction between epidermal antigens binding pemphigus vulgaris and pemphigus foliaceus autoantibodies. J Clin Invest. 1984;74(2):313-320.
Amagai M, Klaus-Kovtun V, Stanley JR. Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. Cell. 1991;67(5):869-877.
Merlob P, Metzker A, Hazaz B et al. Neonatal pemphigus vulgaris. Pediatrics. 1986;78(6):1102-1105.
Anhalt GJ, Labib RS, Voorhees JJ, et al. Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease. N Engl J Med. 1982;306(20):1189-1196.
Amagai M, Tsunoda K, Zillikens D, et al. The clinical phenotype of pemphigus is defined by the anti-desmoglein autoantibody profile. J Am Acad Dermatol. 1999;40(2):167-170.
Mahoney MG, Wang Z, Rothenberger K, et al. Explanation for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris. J Clin Invest. 1999;103(4):461-468.
Anhalt GJ, Kim SC, Stanley JR, et al. Paraneoplastic pemphigus. An autoimmune mucocutaneous disease associated with neoplasia. N Engl J Med. 1990;323(25):1729-1735.
Ho VC, Stein HB, Ongley RA, et al. Penicillamine induced pemphigus. J of Rheumatol. 1985;12(3):583-586.
Diaz LA, Sampaio S, Rivitti EA, et al. Endemic pemphigus foliaceus (fogo selvagem): Current and historical epidemiological aspects. J Invest Dermatol. 1989;92(1):4-12.
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Published
2013-01-31
How to Cite
D’Angelis, C. A. (2013). The Pathology of Pemphigus: A Mini-Review. North American Journal of Medicine and Science, 6(1). Retrieved from https://najms.com/index.php/najms/article/view/168
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