Morphological Variants of Ameloblastoma and Their Mimickers

Khaled Shaikhi, BDS, Mirdza Neiders , DDS, MS, Frank Chen, MD, PhD, Alfredo Aguirre, DDS, MS


Ameloblastoma is the second most common intraosseous benign odontogenic tumor.  This tumor exhibits a locally aggressive behavior.  A number of morphological variants of ameloblastoma have been documented in the literature and at times, may pose a diagnostic challenge to the pathologist. The purpose of this paper is to discuss the spectrum of histopathological variants of ameloblastoma. Recognition of the subtypes of ameloblastoma is important, as it has been documented that some subtypes may exhibit a more aggressive biological behavior than the so-called “conventional” ameloblastoma.   


ameloblastoma, calcifying odontogenic cyst, squamous odontogenic tumor, ameloblastic fibroma, ameloblastic fibrosarcoma, odontogenic keratocyst

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