Transient Visual Loss Associated with the Factor V Leiden Mutation

Richard E Frye, MD, PhD


Transient visual loss may be a manifestation of reduced ophthalamic or cortical perfusion or related to migraine or migraine equivalent phenomenon.  Although transient and permanent loss of vision has been described in several hypercoagulable states, transient visual loss has not been described in patients with the Factor V Leiden mutation.  In this report, we describe two patients this hypercoagulability state that presented to the emergency department with transient visual disturbance.  Although headache was also part of the presenting symptoms, the visual disturbance did not consistently precede the headache in the classical migraine aura pattern.  Several reports have demonstrated an increased incidence of hypercoagulable states in migraine with aura suffers.  It may be that patients with hypercoagulability states have ischemic events that are misclassified as migraine with aura.

[N A J Med Sci. 2017;10(2):61-64.   DOI:  10.7156/najms.2017.1002061]

Full Text:



Schwartz SG. Bilateral combined occlusion of the central retinal artery and vein secondary to thrombotic thrombocytopenic purpura. Arch Ophthalmol. 2000;118:1304-1305.

Peris Martinez C. Branch retinal vein occlusion associated with the 20210 G-to-A prothrombin variant. Eur J Ophthalmol. 2000;10:177-179.

Ushimura S, Mochizuki K, Ohashi M, Ito S, Hosokawa H. Sudden blindness in the fourth month of pregnancy led to diagnosis of moyamoya disease. Ophthalmologica. 1993;207:169-173.

Kupferminc MJ, Yair D, Bornstein NM, Lessing JB, Eldor A. Transient focal neurological deficits during pregnancy in carriers of inherited thrombophilia. Stroke. 2000;31:892-895.

Beg MF, Dempsey PJ, Marsland TG. Transient cortical blindness in a severe preeclamptic. N Z Med J. 1990;103:52.

Kingetsu I, Kurosaka D, Hashimoto N, Tajima N. A case of systemic lupus erythematosus associated with thrombotic thrombocytopenic purpura manifestating homonymous hemianopsia. Nihon Rinsho Meneki Gakkai Kaishi. 1999;22:80-85.

Millot F. Homonymous lateral hemianopsia revealing cerebral thrombophlebitis. Role of a deficiency of protein S induced by l-asparaginase. Presse Med. 2001;30:855-857.

Marinella MA. Stroke after marijuana smoking in a teenager with factor V Leiden mutation. South Med J. 2001;94:1217-1218.

Olcay L. Cerebral infarct associated with factor V Leiden mutation in a boy with hemophilia A. Am J Hematol. 1997;56:189-190.

Szolnoki Z, Somogyvari F, Kondacs A, Szabo M, Fodor L. Evaluation of the interactions of common genetic mutations in stroke subtypes. J Neurol. 2002;249:1391-1397.

Stolz E. Screening for thrombophilic risk factors among 25 German patients with cerebral venous thrombosis. Acta Neurol Scand. 2000;102:31-36.

Kontula K. Arg506Gln factor V mutation (factor V Leiden) in patients with ischaemic cerebrovascular disease and survivors of myocardial infarction. Thromb Haemost. 1995;73:558-560.

Corral J. Migraine and prothrombotic genetic risk factors. Cephalalgia. 1998;18:257-260.

D'Amico D. Genetic abnormalities of the protein C system: shared risk factors in young adults with migraine with aura and with ischemic stroke? Cephalalgia. 1998;18:618-621; discussion 591.

Hering-Hanit R, Friedman Z, Schlesinger I, Ellis M. Evidence for activation of the coagulation system in migraine with aura. Cephalalgia. 2001;21:137-139.

O'Connor PS, Tredici, TJ. Acephalgic migraine. Fifteen years experience. Ophthalmology. 1981;88:999-1003.


  • There are currently no refbacks.