Urate and Parkinson’s Disease: A Novel Biomarker with Potential Prognostic and Therapeutic Values

Xiang Gao, MD, PhD


Urate is a potent antioxidant that effectively scavenges reactive nitrogen and oxygen radicals,1 and therefore, has been thought to have a favorable role in pathogenesis of  Parkinson’s disease (PD). Experimental studies showed that urate reduced oxidative stress primarily through its actions as an effective scavenger of peroxynitrite (ONOO-) and hydroxyl radicals.1, 2 Urate completely prevented the death of the dopaminergic cells in culture induced by homocysteine plus rotenone or by homocysteine plus iron.3 To test the hypothesis that urate is neuroprotective for PD, several epidemiologic studies have been conducted. 

[N A J Med Sci. 2009;2(2):39-40.]

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