Primary Prostatic High-Grade B-Cell Lymphoma with MYC and BCL2 and/or BCL6 Rearrangements: A Case Report and Literature Review

Zhiwei Yin, MD, PhD, Ruifang Zheng, MD, Donghong Cai, MD, PhD


Prostatic lymphoma (mostly secondary involvement) is rare, accounting for 0.09% of all prostate tumors and 0.1% of non-Hodgkin lymphoma. Primary prostate lymphoma is extremely rare, by far only limited number of cases have been reported in English literature. Here we report a case of primary prostatic high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBCL-MBBR) in an 81 year old Caucasian male who presented with urinary outlet obstruction as sole symptom. He was diagnosed as benign prostate hyperplasia, followed with transurethral resection of prostate. Incidentally, a lymphoma was identified on H&E stains. Microscopic finding, Immunohistochemistry, and FISH study all support a diagnosis of HGBCL-MBBR. To our knowledge, this is the first case of HGBCL-MBBR reported so far.

[N A J Med Sci. 2018;11(1):25-27.   DOI:  10.7156/najms.2018.110125]

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