Fasting Triglyceride Concentrations are Associated with Early Mortality Following Antiretroviral Therapy in Zambia

Julius N. Ngu, MD, MPhil, Douglas C. Heimburger, MD, MS, Donna K. Arnett, MSPH, PhD, Christopher K. Nyirenda, MD, Dara Potter, MBA, DrPH


Background: In developing countries, 8 to 71% of patients initiating highly active antiretroviral therapy (HAART) die within the first year of treatment. Apart from baseline CD4 count, viral load, hemoglobin, BMI and stage of the disease, there may be other variables that contribute to AIDS-related mortality. We investigated the potential role of nutrition, lipids and insulin resistance-related phenotypes in predicting early mortality.

 Methods: We recruited 210 HAART-naïve HIV/AIDS patients  in  Lusaka,  Zambia.    Dietary   intake,   anthro-pometric measurement, fasting serum insulin, glucose, and lipid profiles were assessed at baseline. Mortality was assessed after 90 days of follow-up. We used logistic regression models to identify variables associated with mortality

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