Atypical Ductal Hyperplasia of the Breast: A Comprehensive Review

Frank Chen, MD, PhD*, Evan Liu


Atypical Ductal Hyperplasia (ADH) is a histopathological diagnosis frequently encountered in breast tissue biopsies. It stands as a premalignant lesion characterized by cellular proliferation and architectural distortion, positioning itself within the spectrum between benign hyperplasia and ductal carcinoma in situ (DCIS). Notably, ADH bears significant implications for subsequent breast cancer risk. This review delves into the clinical significance, histological features, and molecular alterations of ADH, delving into its association with future breast cancer risk, optimal management approaches, and the impact on patient care. Continued research and collaboration are imperative for optimizing patient care. Throughout this discussion, current research findings are corroborative, underscoring the critical need for precise diagnosis and tailored follow-up to enhance patient outcomes.

[N A J Med Sci. 2023;16(1):006-013.   DOI:  10.7156/najms.2023.1601006]

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