Clear Cell (Tubulo) Papillary Renal Cell Carcinoma: A Case Report and Literature Review of a Recently Recognized New Entity

Adrienne Sauder, Zena Jameel, Charvi Patel, Andrew Golden, Shahida Ahmed, Jin Choe, Donghong Cai


Clear cell (tubulo) papillary renal cell carcinoma (CCPRCC) is a newly established entity in renal tumor classification. Here we report a case of CCPRCC in a 61 year old male with long history of hypertension, chronic renal failure, and one year history of dialysis. Grossly the tumor is multicystic. Microscopically, bland appearing tubules and occasional small papillae with low grade nuclei are noted. The characteristic linear arrangement of nuclei deviating from basal aspect of the lumens is prominent. Immunohistochemically, the tumor cells are positive for CK7, high-molecular weight cytokeratin (HMWK), CA-IX (cup-shape pattern), and negative for AMACR and CD10. The histology and immunophenotype all qualify this tumor as CCPRCC. The diagnostic criteria and the related differential diagnoses are also discussed. 


clear cell (tubule) papillary renal cell carcinoma, diagnostic criteria, immunophenotype, cup-shape pattern of CA-IX

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