Locally Invasive Dermal Squamomelanocytic Tumor: An Uncommon Case of a Biphenotypic Neoplasm that Usually Occurs on Sun-Damaged Skin of Elderly Individuals
Keywords:
melanoma, squamous cell carcinoma, squamomelanocytic, matricoma, biphenotypic, tumor, neoplasmAbstract
We report a locally invasive dermal squamomelanocytic tumor arising on the right jawline of an 85 year old woman with extensive sun damage treated with complete excision. Histological examination revealed a well circumscribed but unencapsulated dermal tumor comprised of epithelioid squamous cells and heavily pigmented melanocytes. AE1/AE3 cytokeratin stain, HMB-45, and Melan-A stain highlight the different component populations. The population of epithelioid squamous cells comprised the predominant population as encountered in other reported cases. The diagnostic features, reported cases, and management of this uncommon tumor were reviewed.
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Leonard N, Wilson N, Calonje JE. Squamomelanocytic tumor: an
unusual and distinctive entity of uncertain biological potential. Am J
Dermatopathol. 2009;31:491-498.
Satter EK, Metcalf J, Lountzis N, et al. Tumors composed of
malignant epithelial and melanocytic populations: a case series and
review of the literature. J Cutan Pathol. 2009;36:211-219.
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uncertain biological potential. Bosn J Basic Med Sci. 2008;8:152-155.
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potential. J Cutan Pathol. 2009; 36: 477-481.
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squamomelanocytic tumour: more evidences. J Eur Acad Dermatol
Venereol. 2011;25:734-735.
Amerio P, Tracanna M, Di Rollo D, et al. Metastasizing dermal
squamomelanocytic tumour. J Eur Acad Dermatol Venereol. 2011; 25;489-491.
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Amin SM, Cooper C, Yelamos O, et al. Combined cutaneous tumors with a melanoma component: a clinical, histologic, and molecular
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nation on the status of cancer, 1975-2010, featuring prevalence of comorbidity and impact on survival among persons with lung, colorectal, breast, or prostate cancer. Cancer. 2014;120:1290-1314.
Karia PS, Han J, Schmults CD. Cutaneous squamous cell carcinoma estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012. J Am Acad Dermatol. 2013;68:957- 966.
Rosen LB, Williams WD, Benson J, et al. A malignant neoplasm with features of both squamous cell carcinoma and malignant melanoma. Am J Dermatopathol. 1984;6:213-219.
Rodic N, Taube JM, Manson P, et al. Locally invasive dermal squamomelanocytic tumor with matrical differentiation: a peculiar case with review of the literature. Am J Dermatopathol. 2013;35:e72-e76.
Boyd AS, Rapini RP. Cutaneous collision tumors. An analysis of 69 cases and review of the literature. Am J Dermatopathol. 1994;16:253- 257.
Miteva H, Herschthal D, Ricotti C, Kerl H, Romanelli P. A rare case of a cutaneous squamomelanocytic tumor: revisiting the histogenesis of combined neoplasms. Am J Dermatopath. 2009;31:599-603.
Resnik KS. Isn’t melanocytic matricoma simply one expected histopathologic expression of matricoma? Am J Dermatopathol. 2003;25:446.
Resnik KS. Is melanocytic matricoma a bona fide entity or is it just one type of matricoma? Am J Dermatopathol. 2003; 25: 166.
Zussman J, Sheth S, Ra SH, et al. Melanocytic matricoma with melanocytic atypia: report of a unique case and review of the literature. Am J Dermatopathol. 2011;33:508-512.
Cartaginese F, Sidoni A. Melanocytic matricoma. Report of a further case with clinicopathological and immunohistochemical findings, differential diagnosis and review of the literature. Histol Histopathol. 2010;25:713-717.
Islam MN, Bhattacharyya I, Proper SA, et al. Melanocytic matricoma: a distinctive clinicopathologic entity. Dermatol Surg. 2007;33:857-863.
Monteagudo C, Fernandez-Figueras MT, San Juan J, et al. Matrical
carcinoma with prominent melanocytic hyperplasia (malignant melanocytic matricoma?) A report of two cases. Am J Dermatopathol. 2003;25:485-489.
Rizzardi C, Brollo A, Colonna A, et al. A tumor with composite pilo- folliculosebaceous differentiation harboring a recently described new entity - melanocytic matricoma. Am J Dermatopathol. 2002; 25: 493- 497.
Rizzardi C, Melato M. Simply, the point is that pathologists should bear in mind melanocytic matricoma. Am J Dermatopathol. 2003;25:447.
Carlson JA, Healy K, Slominski A et al. Melanocytic matricoma: a report of two cases of a new entity. Am J Dermatopathol. 1999;21:344-349.
Brown TJ, Tschen JA. Primary carcinosarcoma of the skin: report of a case and review of the literature. Dermatol Surg. 1999;25:498-500
Pool SE, Manieei F, Clark WH, et al. Dermal squamomelanocytic
tumor: a unique biphenotypic neoplasm of uncertain biological
potential. Hum Pathol. 1999;30:525-529.
Leonard N, Wilson N, Calonje JE. Squamomelanocytic tumor: an
unusual and distinctive entity of uncertain biological potential. Am J
Dermatopathol. 2009;31:491-498.
Satter EK, Metcalf J, Lountzis N, et al. Tumors composed of
malignant epithelial and melanocytic populations: a case series and
review of the literature. J Cutan Pathol. 2009;36:211-219.
Doric M, Radovic S. Dermal squamomelanocytic tumor: neoplasm of
uncertain biological potential. Bosn J Basic Med Sci. 2008;8:152-155.
Rongioletti F, Baldari M, Carli C, et al. Squamomelanocytic tumor: a new case of a unique biphenotypic neoplasm of uncertain biological
potential. J Cutan Pathol. 2009; 36: 477-481.
Amerio P, Carbone A, Auriemma M, et al. Metastasizing dermal
squamomelanocytic tumour: more evidences. J Eur Acad Dermatol
Venereol. 2011;25:734-735.
Amerio P, Tracanna M, Di Rollo D, et al. Metastasizing dermal
squamomelanocytic tumour. J Eur Acad Dermatol Venereol. 2011; 25;489-491.
Weinberg R, Fisher DE, Rich J. Dynamic and transient cancer stem cells nurture melanoma. Nat Med. 2010;16:758.
Amin SM, Cooper C, Yelamos O, et al. Combined cutaneous tumors with a melanoma component: a clinical, histologic, and molecular
study. J Am Acad Dermatol. 2015;73:451-460.
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Published
2016-01-15
How to Cite
Helm, M. A., Xu, H., Schechter, J., & Lin, L. (2016). Locally Invasive Dermal Squamomelanocytic Tumor: An Uncommon Case of a Biphenotypic Neoplasm that Usually Occurs on Sun-Damaged Skin of Elderly Individuals. North American Journal of Medicine and Science, 8(4). Retrieved from https://najms.com/index.php/najms/article/view/81
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