Diagnosis of Concomitant Plasma Cell Myeloma and Chronic Lymphocytic Leukemia in a Single Patient: A Case Report

Sarah Jeong, Xiaolin Wu, Jiehao Zhou


Plasma cell myeloma (PCM) and chronic lymphocytic leukemia (CLL) are hematologic malignancies that occur at different stages of the B-cell maturation pathway. Although both diseases are relatively common malignancies in elderly individuals, their concomitant occurrence in one patient is rare. Here we report a patient with a 9-year history of CLL who was subsequently diagnosed with coexisting PCM after she was found to have bilateral pathologic clavicular fractures. We provide immunohistological and immunophenotypic evidence for these separate and simultaneous diseases within the same patient.


chronic lymphocytic leukemia, multiple myeloma, concomitant, B-cell disorder, hematologic malignancy

Full Text:



Barlogie, B, Gale, RP. Multiple myeloma and chronic lymphocytic leukemia: Parallels and contrasts. Am J Med. 1992;93:443-450.

Jemal, A, Siegel, R, Ward, E, et al. Cancer Statistics, 2008. CA Cancer J Clin. 2008;58:71-96.

McKenna, R.W., Kule, R.A., Kuehl, W.M., Grogan, T.M., Harris. N.L., Coupland, R.W. Plasma cell neoplasms. In: Swerdlow, S.H., Campo, E., Harris, N.L., et al, eds. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues.4th ed. Lyon, France. IARC Press; 2008:200-213. World Health Organization Classification of Tumours; vol 2.

Alley, CL, Wang, E, Dunphy, CH, et al. Diagnostic and Clinical Considerations in Concomitant Bone Marrow Involvement by Plasma Cell Myeloma and Chronic Lymphocytic Leukemia/Monoclonal B-Cell Lymphocytosis: A Series of 15 Cases and Review of Literature. Arch Pathol Lab Med. 2013;137:503–517.

Pereira, W, Bacal, N, Correia, R, et al. Development of plasma cell myeloma in a B-cell chronic lymphocytic leukemia patient with chromosome 12 trisomy. BMC Res Notes. 2013;6:433.

Brouet, JC, Fermand, JP, Laurent, G, et al. The association of chronic lymphocytic leukaemia and multiple myeloma: a study of eleven patients. Br J Haematol. 1985;59:55-66.

Fermand, JP, James, JM, Herait, P, Brouet, JC. Associated chronic lymphocytic leukemia and multiple myeloma: origin from a single clone. Blood. 1985;66:291-293.

Zalcberg, JR, Cornell, FN, Ireton, HJC, et al. Chronic lymphatic leukemia developing in a patient with multiple myeloma. Immunologic demonstration of a clonally distinct second malignancy. Cancer. 1982;50:594-597.

Novak, PM, Mattson, JC, Crisan, D, Chen, J, Poulik, MD, Decker, D. Separate clones in concomitant multiple myeloma and a second B-cell neoplasm demonstrated by molecular and immunophenotypic analysis. Eur J Hematol. 2009;54:254-261.

Saltman, DL, Ross, JA, Banks, RE, Ross, FM, Ford, AM, Mackie, MJ. Molecular evidence for a single clonal origin in biphenotypic concomitant chronic lymphocytic leukemia and multiple myeloma. Blood. 1989;74:2062-2065.

Patriarca, F, Gaidano, G, Capello, D, Zaja, F, Fanin, R, Baccarani, M. Occurrence of multiple myeloma after fludarabine treatment of a chronic lymphocytic leukemia: evidence of a biclonal derivation and clinical response to autologous stem cell transplantation. Haematologica. 2000;85:982-985.

Kaufmann, H., Ackermann, J., Nösslinger, T., Krömer, E., Zojer, N., Schreiber, S., et al. Absence of clonal chromosomal relationship between concomitant B-CLL and multiple myeloma - a report on two cases. Ann Hematol. 2001;80:474-478.

Aktan, M, Akkaya, A, Doğan, O, Dincol, G. Chronic Lymphocytic Leukemia and Multiple Myeloma in the Same Patient: Case Report. Leuk Lymphoma. 2003;44:1421-1424.

Kough, RH, Makary, AZ. Chronic lymphocytic leukemia (CLL) terminating in multiple myeloma: report of two cases. Blood. 52:532-536.

Makower, D, Venkatraj, U, Dutcher, JP, Wiernik, PH. Occurrence of Myeloma in a Chronic Lymphocytic Leukemia Patient After Response to Differentiation Therapy with Interleukin-4. Leuk Lymphoma. 1996;23:617-619.

Pines, A, Ben-Bassat, I, Selzer, G, Ramot, B. Transformation of chronic lymphocytic leukemia to plasmacytoma. Cancer. 1984;54:1904-1907.


  • There are currently no refbacks.