Validity of Fine Needle Aspiration Cytology in Diagnosis of Prostatic Lesions and Correlation with Trucut Biopsy

Judith J. Thangaiah, MD, Krishna Balachandran, MD, Usha Poothiode, MD, Suresh Bhat, MD


Prostate fine needle aspiration (FNA) is an easy-to-perform outpatient procedure requiring no expensive equipment or anesthesia. The aim of this study was to analyze the cytomorphology of prostatic lesions and to correlate the findings in cytology with that of the histopathological appearance. In doing so we also assessed the diagnostic accuracy of fine needle aspiration cytology and identified possible pitfalls. The study was carried out in 100 patients who underwent tru-cut biopsy in the department of Urology at Kottayam Medical College, India during the period spanning from March 2010 to March 2011. Fine needle aspiration cytology (FNAC) was done with Franzen needle and followed by tru-cut biopsy after which the results of both were compared. FNAC gave a benign diagnosis in 64 cases and identified a malignant pattern in 36 cases. The overall accuracy of FNAC in this series in diagnosing prostatic lesions was 97% with a sensitivity of 100% and specificity of 95.5%. This shows that FNAC prostate is a reliable, relatively painless tool, which can be used for the diagnosis of prostatic carcinoma, especially in patients with high risk complications such as bleeding and infections in whom a tru-cut biopsy is more invasive. In addition it is also cost-effective and may sample a larger area.


fine needle aspiration cytology, prostate, Franzen needle, correlation of cytology and biopsy

Full Text:



Franzen S, Giertz G, Zajicek J. Cytological diagnosis of prostatic tumours by transrectal aspiration biopsy: a preliminary report. Br J Urol. 1960;32:193-196.

Benson MC. Fine-needle aspiration of the prostate. NCI monogr. 1988(7):19-24.

Chodak GW, Bibbo M, Straus FH, 2nd, Wied GL. Transrectal aspiration biopsy versus transperineal core biopsy for the diagnosis of carcinoma of the prostate. J Urol. 1984;132(3):480-482.

Maksem JA, Park CH, Johenning PW, Galang CF, Tannenbaum M. Aspiration biopsy of the prostate gland. Urol Clin North Am. 1988;15(4):555-575.

Cullmann HJ. [Current value of transrectal fine needle biopsy. High predictive value in the diagnosis of prostate carcinoma, minimal discomfort to the patient]. MMW Fortschr Med. 1991;109(26):518-520.

Andersson L, Hagmar B, Ljung BM, Skoog L. Fine needle aspiration biopsy for diagnosis and follow-up of prostate cancer. Consensus Conference on Diagnosis and Prognostic Parameters in Localized Prostate Cancer. Scand J Urol Nephrol Suppl. 1994;162:43-49.

Willems JS, Lowhagen T. Transrectal fine-needle aspiration biopsy for cytologic diagnosis and grading of prostatic carcinoma. Prostate. 1981;2(4):381-395.

Zattoni F, Pagano F, Rebuffi A, Costantin G. Transrectal thin-needle aspiration biopsy of prostate: four years' experience. Urology. 1983;22(1):69-72.

Saleh AF, Nahar Rahman AJ, Salam MA, Islam F. Role of fine needle aspiration cytology (FNAC) in the diagnosis of prostatic lesions with histologic correlation. Bangladesh Med Res Counc Bull. 2005;31(3):95-103.

Singh N, Shenoi UD, Raghuveer CV. FNAC and transabdominal ultrasonography in the diagnosis of prostatomegaly. Indian J Pathol Microbiol. 1997;40(4):473-479.

Polito M, Alberti R, Muzzonigro G, Baldi A, Diambrini M, Vecchi A. Fine needle aspiration biopsy of the prostate gland: our experience concerning 101 cases with histological follow-up. Prostate. 1990;17(2):85-94.

Honig SC, Stilmant MM, Klavans MS, Freedlund MC, Siroky MB. The role of fine-needle aspiration biopsy of the prostate in staging adenocarcinoma. Cancer. 1992;69(12):2978-2982.

Klotz LH, Shaw PA, Srigley JR. Transrectal fine-needle aspiration and truecut needle biopsy of the prostate: a blinded comparison of accuracy. Can J Surg. 1989;32(4):287-289.

Maksem JA, Johenning PW. Is cytology capable of adequately grading prostate carcinoma? Matched series of 50 cases comparing cytologic and histologic pattern diagnoses. Urology. 1988;31(5):437-444.

Hostetter AL, Pedersen KV, Gustafsson BL, Manson JC, Boeryd BR. Diagnosis and localization of prostate carcinoma by fine-needle aspiration cytology and correlation with histologic whole-organ sections after radical prostatectomy. Am J Clin Pathol. 1990;94(6):693-697.

Adolfsson J, Skoog L, Lowhagen T, Waisman J. Franzen transrectal fine-needle biopsy versus ultrasound-guided transrectal core biopsy of the prostate gland. Acta Oncol. 1991;30(2):159-160.


  • There are currently no refbacks.