Plasma Amyloid- Peptides and Homocysteine in Depression in the Homebound Elderly

Wei Qiao Qiu, MD, PhD, Xiaoyan Sun, MD, PhD, D. Mkaya Mwamburi, MD, PhD, Jacqueline Haker, BA


Objectives:  Both plasma amyloid-b peptide 40 (Ab40) and homocysteine (tHcy) are linked to vascular disease, which is related to depression in the elderly.  We sought to study whether the relationship between tHcy and plasma Ab40 differs in those with and without depression.


Study Design and Methods: In a cross-sectional study of 1058 homebound elders, vascular depression was defined as a score > 16 on the Center for Epidemiological Studies Depression scale (CES-D) along with self-reported cardiovascular disease (CVD).  Plasma Ab40 and Ab42, and serum tHcy and creatinine were measured.

Full Text:



  • There are currently no refbacks.