Solar Lentigo Evolving into Fatal Metastatic Melanoma in a Patient Who Initially Refused Surgery

Michael Shatkin, MS, Matthew F Helm, MD*, Aaron Muhlbauer, MD, Catherine G Chung, MD


Lentigo maligna may not progress to invasive disease for many decades.  We present the unusual case of a woman who underwent well documented periodic evaluations and occasional biopsies of a nasal lesion that gradually progressed from lentigo, to melanoma in situ of lentigo maligna type, to invasive disease, and finally to fatal metastatic melanoma.  She had declined curative resection of her tumor for cosmetic reasons.  Her clinical course is unusual in that photographs and biopsies document the progression from solar lentigo to fatal disease.

[N A J Med Sci. 2020;1(1):028-031.   DOI:  10.7156/najms.2020.1301028]


Key Words: melanoma; lentigo maligna; metastasis; squamous cell carcinoma; solar lentigo; unstable lentigo

*Corresponding Author: Penn State Milton S. Hershey Medical Center, Department of Dermatology HU14, 500 University Drive, Suite 100, Hershey, PA 17033. Tel: 717-531-6820, Fax: 717-531-4702. (Email:

Full Text:



  • There are currently no refbacks.